nlrp3 inhibitor mcc950 (MedChemExpress)
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MedChemExpress
nlrp3 inhibitor mcc950
Nlrp3 Inhibitor Mcc950, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 636 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/nlrp3+inhibitor+mcc950/MCC950/pmc13223851-69-6-13
Average 99 stars, based on 636 article reviews
Nlrp3 Inhibitor Mcc950, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 636 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/nlrp3+inhibitor+mcc950/MCC950/pmc13223851-69-6-13
Average 99 stars, based on 636 article reviews
nlrp3 inhibitor mcc950 - by Bioz Stars,
2026-09
99/100 stars
Images
1) Product Images from "8-oxo-7,8-dihydroguanosine (8-oxo-Guo) drives pulmonary inflammatory pathways through pattern recognition receptors"
Article Title: 8-oxo-7,8-dihydroguanosine (8-oxo-Guo) drives pulmonary inflammatory pathways through pattern recognition receptors
Journal: Redox Biology
doi: 10.1016/j.redox.2026.104211
Figure Legend Snippet: 8-oxo-Guo and polyU stimulate inflammation via NLR and TLR signaling pathways. (A, B) Transcriptome analysis of MH-S cells following 2-h stimulation with 8-oxo-Guo and/or polyU. (A) KEGG pathway enrichment analysis. (B) GSEA. (C) Relative mRNA expression levels of NOD2 , TLR2 , and NLRP3 in cells after 2-h stimulation with 8-oxo-Guo and/or polyU. ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001. (D) Protein expression changes and grayscale quantification of key components of NLR, TLR, MAPK, JAK-STAT, and NF-κB signaling pathways following 2-h stimulation with 8-oxo-Guo and/or polyU. ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001.
Techniques Used: Protein-Protein interactions, Expressing
Figure Legend Snippet: Dose-dependent suppression of 8-oxo-Guo/polyU-induced inflammation upon NOD2, TLR2, and NLRP3 inhibition. (A-F) Protein expression changes in NLR, TLR, and downstream signaling pathways (left panels) and concentrations of TNF-α, MIP-2, IL-1β, and MCP-1 in the culture supernatant (right panels) of MH-S cells following 4-h co-stimulation with 8-oxo-Guo and polyU in the presence of GSK717 (A, B) , Cu-CPT22 (C, D) , or MCC950 (E, F) . ∗∗ p < 0.01, ∗∗∗ p < 0.001. (G, H) Protein expression profiles of relevant signaling pathways (G) and cytokine concentrations in the culture supernatant (H) of MH-S cells that were treated for 4 h with 8-oxo-Guo and polyU combined with GSK717, Cu-CPT22, or MCC950, either individually or combined. ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001.
Techniques Used: Inhibition, Expressing, Protein-Protein interactions
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